FNDC3A

Across TCGA pan-cancer cohorts, FNDC3A RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated FNDC3A data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher FNDC3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FNDC3A expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

CESC, KIRC, and LUSC are the cancer types where FNDC3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.444	0.628	<.001	112	view →
KIRC	DFS	Median	All	0.723	0.539	<.001	109	view →
LUSC	DFS	Median	II,III,IV	0.275	0.519	<.001	98	view →
UVM	DFS	Quartile	III,IV	0.170	0.792	.006	27	view →
UCEC	DFS	Quartile	II,III,IV	0.906	0.747	.008	26	view →
MESO	DFS	Quartile	III,IV	0.139	0.671	.010	21	view →
LGG	OS	Median	All	0.341	0.615	<.001	21	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	18	view →
BLCA	DFS	Quartile	All	0.199	0.593	.008	16	view →
ACC	DFS	Median	III,IV	0.544	0.149	.024	15	view →
BRCA	DFS	Median	III,IV	0.924	0.829	.010	15	view →
HNSC	OS	Tertile	III,IV	0.538	0.856	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

FNDC3A–CESC (DFS)

Open the CESC breakdown →