FNDC1-IT1

Across TCGA pan-cancer cohorts, FNDC1-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FNDC1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FNDC1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FNDC1-IT1 is over-expressed in tumor.

HNSC, LUAD, and BRCA are the cancer types where FNDC1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FNDC1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.220	<.001	10	view →
LUAD	Female	II,III,IV	+0.490	<.001	9	view →
BRCA	Female	II,III,IV	+0.461	<.001	6	view →
BLCA	All	All	+0.218	.018	6	view →
LUSC	All	II,III,IV	+0.353	<.001	5	view →
COAD	All	All	+0.147	.014	5	view →
STAD	All	II,III,IV	+0.123	.006	4	view →
KIRC	All	II,III,IV	+0.033	.039	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FNDC1-IT1–HNSC

Open the HNSC breakdown →