FN1

Across TCGA cell cohorts, FN1 mutation is significantly associated with the RNA expression of many other genes, with 749 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FN1-associated genes across cancer lineages are FAM98C, SLC29A4, and ITGAD. Each is linked with FN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FN1-to-partner and partner-to-FN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM98C grouped by FN1-low versus FN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FN1→partner) and Y-score (partner→FN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM98C →	+0.710	+3.214	<.001	.006	3	3
BLOOD_Leukemia	SLC29A4 →	+1.084	+3.614	<.001	<.001	3	3
BREAST	ITGAD →	+0.120	+4.199	<.001	.007	3	3
OVARY	PGAP2 →	+0.739	+2.269	.001	.007	3	3
LARGE_INTESTINE	CATSPER3 →	+0.373	+3.130	<.001	<.001	3	3
PANCREAS	FAM90A26 →	+0.006	+3.139	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 749 associations by consensus.

FAM98C by FN1 expression — BLOOD_Leukemia

Explore this box plot interactively →