FMR1NB

Across TCGA patient cohorts, FMR1NB mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMR1NB-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and PCNA. Each is linked with FMR1NB in more than 2 cancer types. Because this analysis shows association rather than direction, both FMR1NB-to-partner and partner-to-FMR1NB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FMR1NB-low versus FMR1NB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1NB→partner) and Y-score (partner→FMR1NB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.467	-1.415	.006	.046	3	3
UCEC	JNK_pT183_Y185 →	-0.175	-1.752	.005	.014	3	2
UCEC	PCNA →	+0.265	+2.169	.001	.003	3	2
UCEC	Rab25 →	-0.366	-3.321	.003	.009	3	2
UCEC	Caspase-8 →	-0.249	-2.295	.008	.005	3	2
UCEC	EGFR_pY1068 →	-0.274	-2.906	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ATM by FMR1NB expression — UCEC

Explore this box plot interactively →