FMR1

Across TCGA patient cohorts, FMR1 mutation is significantly associated with the RNA expression of many other genes, with 5,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMR1-associated genes across cancer lineages are CDADC1, NEURL1, and PINK1-AS. Each is linked with FMR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMR1-to-partner and partner-to-FMR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDADC1 grouped by FMR1-low versus FMR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1→partner) and Y-score (partner→FMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDADC1 →	+0.256	+1.447	<.001	<.001	3	3
UCEC	NEURL1 →	-0.476	-2.381	.001	<.001	3	3
UCEC	PINK1-AS →	+0.481	+1.702	<.001	<.001	3	3
UCEC	DNAJC8 →	+0.373	+1.862	<.001	<.001	3	3
LUSC	SRRM1 →	+0.587	+3.204	<.001	.009	3	3
UCEC	ITGB7 →	+0.396	+1.171	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,620 associations by consensus.

CDADC1 by FMR1 expression — UCEC

Explore this box plot interactively →