FMR1-IT1

Across TCGA pan-cancer cohorts, FMR1-IT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FMR1-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FMR1-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FMR1-IT1 expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

KIRC, UCEC, and READ are the cancer types where FMR1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.569	0.687	.001	89	view →
UCEC	DFS	Quartile	All	0.595	0.810	.003	78	view →
READ	OS	Median	II,III,IV	0.915	0.689	<.001	51	view →
BLCA	DFS	Quartile	IV	0.230	0.641	<.001	24	view →
SKCM	OS	Tertile	IV	1.000	0.287	.006	23	view →
PRAD	OS	Quartile	All	0.838	1.000	.006	22	view →
UCS	OS	Tertile	II,III,IV	0.686	0.247	.009	20	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	17	view →
LGG	DFS	Quartile	All	0.780	0.897	.001	17	view →
ACC	OS	Tertile	II,III,IV	0.905	0.411	.012	16	view →
COAD	OS	Tertile	II,III,IV	0.837	0.665	.018	15	view →
KIRP	DFS	Quartile	All	0.566	0.810	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FMR1-IT1–KIRC (OS)

Open the KIRC breakdown →