FMR1-IT1

Across TCGA pan-cancer cohorts, FMR1-IT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FMR1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FMR1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FMR1-IT1 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where FMR1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FMR1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.300	<.001	8	view →
LIHC	All	All	+0.326	<.001	6	view →
BRCA	Female	All	−0.310	.002	6	view →
CHOL	All	II,III,IV	+2.610	.005	4	view →
COAD	All	All	+0.394	.008	4	view →
BLCA	Female	IV	+0.970	.036	3	view →
ESCA	All	All	+0.800	.004	2	view →
KICH	All	II,III,IV	+0.387	.036	2	view →
KIRC	Female	IV	−0.518	.017	1	view →
STAD	All	All	+0.384	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FMR1-IT1–HNSC

Open the HNSC breakdown →