FMR1-AS1

Across TCGA pan-cancer cohorts, FMR1-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FMR1-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher FMR1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FMR1-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and THYM show a favorable association.

KICH, BLCA, and LUSC are the cancer types where FMR1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.257	0.885	.005	44	view →
BLCA	DFS	Tertile	IV	0.204	0.617	<.001	38	view →
LUSC	DFS	Median	III,IV	0.545	0.745	.009	24	view →
READ	OS	Median	II,III,IV	0.787	0.391	.002	23	view →
LUAD	DFS	Quartile	IV	0.296	0.731	.006	20	view →
UVM	DFS	Tertile	III,IV	0.154	0.856	.007	13	view →
CHOL	DFS	Tertile	III,IV	0.163	0.779	.024	12	view →
GBM	OS	Tertile	All	0.187	0.331	<.001	12	view →
SKCM	DFS	Median	IV	0.187	0.763	.006	12	view →
UCEC	OS	Quartile	All	0.625	0.790	.020	10	view →
SARC	OS	Median	All	0.425	0.595	.020	7	view →
KIRP	DFS	Median	All	0.378	0.723	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FMR1-AS1–KICH (DFS)

Open the KICH breakdown →