FMR1-AS1

Across TCGA pan-cancer cohorts, FMR1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FMR1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FMR1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types FMR1-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where FMR1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FMR1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.298	<.001	10	view →
KIRC	Female	All	−0.133	<.001	10	view →
LIHC	All	All	+0.086	<.001	6	view →
COAD	All	All	+0.073	.001	6	view →
KIRP	Male	All	−0.115	<.001	4	view →
STAD	All	II,III,IV	+0.097	.013	4	view →
LUSC	All	All	+0.076	<.001	4	view →
LUAD	Male	All	+0.071	<.001	4	view →
HNSC	Male	All	+0.035	.003	3	view →
PRAD	All	All	−0.027	.018	2	view →
KICH	Female	All	−0.139	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FMR1-AS1–THCA

Open the THCA breakdown →