FMO5

Across TCGA pan-cancer cohorts, FMO5 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FMO5 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher FMO5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FMO5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

OV, LUAD, and COAD are the cancer types where FMO5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.076	0.844	<.001	48	view →
LUAD	OS	Median	All	0.111	0.835	<.001	36	view →
COAD	OS	Median	All	0.135	0.675	<.001	22	view →
SKCM	DFS	Median	All	0.910	0.611	.016	13	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	1.000	0.487	.037	6	view →
STAD	DFS	Median	All	1.000	0.340	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FMO5–OV (OS)

Open the OV breakdown →