FMO5

Across TCGA patient cohorts, FMO5 mutation is significantly associated with the RNA expression of many other genes, with 2,439 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO5-associated genes across cancer lineages are RNA5SP413, TUBGCP5, and IGHD5-12. Each is linked with FMO5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMO5-to-partner and partner-to-FMO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by FMO5-low versus FMO5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO5→partner) and Y-score (partner→FMO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP413 →	+0.579	+4.496	.003	.007	3	3
UCEC	TUBGCP5 →	+0.403	+3.818	.002	<.001	3	2
READ	IGHD5-12 →	+1.287	+4.421	<.001	.009	3	2
READ	RPL35AP3 →	+0.594	+4.533	<.001	.004	3	2
READ	BPNT2P →	+0.111	+5.681	<.001	.001	3	2
BLCA	CXADRP2 →	+0.107	+3.883	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,439 associations by consensus.

RNA5SP413 by FMO5 expression — LUSC

Explore this box plot interactively →