FMO1

Across TCGA cell cohorts, FMO1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FMO1-associated genes across cancer lineages are IL36B, OR5P2, and KRTAP24-1. Each is linked with FMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMO1-to-partner and partner-to-FMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36B grouped by FMO1-low versus FMO1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO1→partner) and Y-score (partner→FMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL36B →	+0.032	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5P2 →	+0.032	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP24-1 →	+0.073	+6.247	<.001	<.001	3	1
SKIN	SERPINA4 →	+0.004	+3.345	<.001	.007	3	1
SKIN	IL17F →	+0.023	+3.632	<.001	.003	3	1
SKIN	CEACAM8 →	+0.007	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IL36B by FMO1 expression — BLOOD_Lymphoma

Explore this box plot interactively →