Across TCGA patient cohorts, FMNL1 mutation is significantly associated with the RNA expression of many other genes, with 5,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMNL1-associated genes across cancer lineages are MRPS27, GEMIN2, and RNA5SP412. Each is linked with FMNL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FMNL1-to-partner and partner-to-FMNL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMNL1→partner) and Y-score (partner→FMNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS27 →	+0.425	+3.269	<.001	<.001	3	4
UCEC	GEMIN2 →	+0.373	+1.747	.002	<.001	3	4
UCEC	RNA5SP412 →	+0.478	+1.967	<.001	<.001	3	3
SKCM	GPHN →	+0.701	+2.610	<.001	.005	3	3
SKCM	SF3A3 →	+0.479	+3.604	.001	.001	3	3
UCEC	EMID1 →	-1.278	-1.943	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,037 associations by consensus.

Exploration

FMNL1 survival (RNA) · tumor vs normal (RNA) · all FMNL1 data types