FMN1

Across TCGA patient cohorts, FMN1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMN1-associated genes across cancer lineages are GAPDH, Tuberin_pT1462, and eEF2. Each is linked with FMN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMN1-to-partner and partner-to-FMN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by FMN1-low versus FMN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMN1→partner) and Y-score (partner→FMN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.334	+1.440	.022	.020	3	3
STAD	Tuberin_pT1462 →	-0.207	-3.321	.023	.010	3	2
UCEC	eEF2 →	+0.307	+2.247	.001	.001	3	2
UCEC	ERK2 →	+0.221	+2.523	<.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.081	-1.191	.016	.025	3	2
UCEC	MEK1 →	+0.382	+1.765	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

GAPDH by FMN1 expression — UCEC

Explore this box plot interactively →