FMN1

Across TCGA cell cohorts, FMN1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FMN1-associated genes across cancer lineages are ZNF454, LACTBL1, and DEFB132. Each is linked with FMN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMN1-to-partner and partner-to-FMN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF454 grouped by FMN1-low versus FMN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMN1→partner) and Y-score (partner→FMN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF454 →	+0.251	+2.921	<.001	.005	3	2
LARGE_INTESTINE	LACTBL1 →	+0.026	+3.632	.001	<.001	3	2
STOMACH	DEFB132 →	+0.084	+4.285	<.001	.007	3	2
LIVER	KRT33A →	+0.056	+4.000	<.001	.001	3	1
PANCREAS	TAAR8 →	+0.017	+4.614	<.001	.004	3	1
PANCREAS	PRKACG →	+0.005	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ZNF454 by FMN1 expression — LARGE_INTESTINE

Explore this box plot interactively →