FMC1

Across TCGA pan-cancer cohorts, FMC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FMC1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FMC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FMC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where FMC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.571	0.820	.003	34	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.597	.008	17	view →
PDAC	DFS	Quartile	All	0.694	0.387	.005	8	view →
UCEC	DFS	Tertile	II,III,IV	0.916	0.489	.035	4	view →
GBM	DFS	Median	All	0.834	0.626	.007	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FMC1–HNSC (OS)

Open the HNSC breakdown →