FLYWCH2

Across TCGA pan-cancer cohorts, FLYWCH2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FLYWCH2 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FLYWCH2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FLYWCH2 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

HNSC, GBM, and LUAD are the cancer types where FLYWCH2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.296	1.000	.003	46	view →
GBM	OS	Tertile	All	0.681	0.351	.001	25	view →
LUAD	OS	Quartile	II,III,IV	0.850	0.404	.013	17	view →
CCRCC	OS	Median	All	0.906	1.000	.016	10	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →
LSCC	OS	Median	All	0.813	0.953	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FLYWCH2–HNSC (OS)

Open the HNSC breakdown →