FLT3LG

Across TCGA cell cohorts, FLT3LG RNA expression is significantly associated with the go_rna of many other GO terms, with 5,113 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FLT3LG-associated GO terms across cancer lineages are Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, Negative regulation of response to biotic stimulus, and ISG15-protein conjugation. Each is linked with FLT3LG in more than 14 cancer types. Because this analysis shows association rather than direction, both FLT3LG-to-partner and partner-to-FLT3LG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of exogenous peptide antigen via MHC class Ib grouped by FLT3LG-low versus FLT3LG-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT3LG→partner) and Y-score (partner→FLT3LG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.247	+1.379	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of response to biotic stimulus →	+0.109	+1.545	<.001	<.001	3	14
URINARY_TRACT	ISG15-protein conjugation →	+0.202	+1.188	.003	.007	2	15
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.257	+1.505	<.001	<.001	3	13
SOFT_TISSUE	Regulation of extrinsic apoptotic signaling pathway →	+0.073	+1.330	<.001	<.001	2	14
KIDNEY	Maintenance of protein localization in organelle →	+0.123	+1.125	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,113 associations by consensus.

Antigen processing and presentation of exogenous peptide antigen via MHC class Ib by FLT3LG expression — BREAST

Explore this box plot interactively →