FLT3

Across TCGA cell cohorts, FLT3 mutation is significantly associated with the RNA expression of many other genes, with 293 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLT3-associated genes across cancer lineages are ARMC3, FAM81B, and SPANXN5. Each is linked with FLT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLT3-to-partner and partner-to-FLT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMC3 grouped by FLT3-low versus FLT3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT3→partner) and Y-score (partner→FLT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARMC3 →	+0.109	+3.754	.002	.008	3	2
LARGE_INTESTINE	FAM81B →	+0.202	+3.918	.007	<.001	3	2
LUNG_SCLC	SPANXN5 →	+0.062	+4.269	.002	.005	3	2
BLOOD_Leukemia	SPATA8 →	+0.022	+2.668	<.001	.005	3	2
SOFT_TISSUE	ZNF735 →	+0.154	+4.369	<.001	.008	3	1
OESOPHAGUS	KHDRBS2 →	+0.603	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 293 associations by consensus.

ARMC3 by FLT3 expression — BLOOD_Lymphoma

Explore this box plot interactively →