FLRT1

Across TCGA patient cohorts, FLRT1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLRT1-associated genes across cancer lineages are eEF2, JNK2, and IGFBP2. Each is linked with FLRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLRT1-to-partner and partner-to-FLRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FLRT1-low versus FLRT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLRT1→partner) and Y-score (partner→FLRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.294	+2.321	.012	.033	3	2
UCEC	JNK2 →	+0.226	+2.257	<.001	<.001	3	2
UCEC	IGFBP2 →	-0.940	-3.115	<.001	<.001	3	1
UCEC	MEK1 →	+0.267	+1.847	.026	.007	3	1
UCEC	p62 Lck ligand →	+0.233	+1.906	.029	.014	3	1
UCEC	PCNA →	+0.153	+2.115	.032	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by FLRT1 expression — UCEC

Explore this box plot interactively →