FLRT1

Across TCGA cell cohorts, FLRT1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLRT1-associated genes across cancer lineages are MTRNR2L5, KRTAP21-2, and OR6C74. Each is linked with FLRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLRT1-to-partner and partner-to-FLRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L5 grouped by FLRT1-low versus FLRT1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLRT1→partner) and Y-score (partner→FLRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MTRNR2L5 →	+0.053	+4.807	<.001	.006	3	2
LUNG_SCLC	KRTAP21-2 →	+0.121	+5.169	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR6C74 →	+0.092	+6.247	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SLC35G4 →	+0.022	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPATS1 →	+0.106	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	TEX43 →	+0.083	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MTRNR2L5 by FLRT1 expression — BLOOD_Myeloma

Explore this box plot interactively →