FLOT1

Across TCGA pan-cancer cohorts, FLOT1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FLOT1 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FLOT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FLOT1 expression acts as an unfavorable survival marker.

COAD, LUSC, and LIHC are the cancer types where FLOT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.221	0.782	.013	9	view →
LUSC	DFS	Median	All	0.027	0.749	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.318	0.637	.030	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FLOT1–COAD (OS)

Open the COAD breakdown →