FLOT1

Across TCGA pan-cancer cohorts, FLOT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FLOT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FLOT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FLOT1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where FLOT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLOT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.559	<.001	12	view →
KIRC	Female	All	+0.677	<.001	11	view →
LIHC	Female	II,III,IV	+1.254	<.001	9	view →
KICH	Female	II,III,IV	−1.728	<.001	8	view →
BRCA	All	III,IV	+0.511	<.001	6	view →
CHOL	All	All	+2.286	<.001	5	view →
STAD	Male	II,III,IV	+0.876	<.001	5	view →
ESCA	All	All	+0.820	.001	3	view →
BLCA	Male	IV	−0.917	.034	2	view →
COAD	Female	All	+0.284	.003	2	view →
STAD	Female	III,IV	−0.475	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

FLOT1–HNSC

Open the HNSC breakdown →