FLNC

Across TCGA patient cohorts, FLNC protein abundance is significantly associated with the RNA expression of many other genes, with 12,605 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FLNC-associated genes across cancer lineages are DES, TPM2, and MYL9. Each is linked with FLNC in more than 9 cancer types. Because this analysis shows association rather than direction, both FLNC-to-partner and partner-to-FLNC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FLNC versus DES in HNSC, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNC→partner) and Y-score (partner→FLNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DES →	+4.958	+1.497	<.001	<.001	3	10
HNSC	TPM2 →	+1.443	+0.951	<.001	<.001	3	10
UCEC	MYL9 →	+1.330	+0.808	<.001	<.001	3	9
OV	ACTA2 →	+2.194	+0.746	<.001	<.001	3	9
OV	TGFB3 →	+1.475	+0.653	<.001	<.001	3	9
OV	CALD1 →	+1.365	+0.670	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,605 associations by consensus.

FLNC vs DES — HNSC

Explore this scatter interactively →