FLNC

Across TCGA pan-cancer cohorts, FLNC RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated FLNC data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher FLNC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FLNC expression acts as an unfavorable survival marker, although some lineages such as LAML and UCS show a favorable association.

LUSC, UVM, and BLCA are the cancer types where FLNC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.690	0.823	<.001	92	view →
UVM	DFS	Median	All	0.402	0.732	<.001	90	view →
BLCA	OS	Median	All	0.531	0.692	<.001	89	view →
LUAD	OS	Quartile	All	0.535	0.739	<.001	75	view →
KIRC	OS	Tertile	All	0.743	0.862	<.001	73	view →
MESO	DFS	Median	II,III,IV	0.290	0.611	.006	66	view →
LGG	OS	Median	All	0.339	0.555	<.001	54	view →
KICH	OS	Tertile	III,IV	0.221	0.894	.002	46	view →
THCA	OS	Median	II,III,IV	0.792	1.000	.003	37	view →
LAML	DFS	Median	All	0.545	0.229	.008	34	view →
OV	DFS	Median	All	0.497	0.581	.008	30	view →
LIHC	OS	Quartile	All	0.539	0.789	<.001	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

FLNC–LUSC (DFS)

Open the LUSC breakdown →