FLNC

Across TCGA patient cohorts, FLNC mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLNC-associated genes across cancer lineages are GAPDH, eIF4E, and Annexin_VII. Each is linked with FLNC in more than 4 cancer types. Because this analysis shows association rather than direction, both FLNC-to-partner and partner-to-FLNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by FLNC-low versus FLNC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNC→partner) and Y-score (partner→FLNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.496	+1.836	<.001	<.001	3	5
COAD	eIF4E →	+0.200	+3.087	<.001	<.001	3	4
BRCA	Annexin_VII →	-0.194	-2.993	.011	.037	3	4
UCEC	4E-BP1 →	+0.314	+1.402	<.001	<.001	3	4
COAD	ASNS →	+0.563	+2.178	<.001	<.001	3	4
UCEC	ATM →	-0.610	-2.035	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

GAPDH by FLNC expression — SKCM

Explore this box plot interactively →