FLNC

Across TCGA cell cohorts, FLNC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,777 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FLNC-associated GO terms across cancer lineages are Protein-containing complex disassembly, Positive regulation of cell-substrate adhesion, and Regulation of intracellular transport. Each is linked with FLNC in more than 12 cancer types. Because this analysis shows association rather than direction, both FLNC-to-partner and partner-to-FLNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-containing complex disassembly grouped by FLNC-low versus FLNC-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNC→partner) and Y-score (partner→FLNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Protein-containing complex disassembly →	+0.068	+2.819	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.107	+3.621	<.001	.001	3	12
BONE	Regulation of intracellular transport →	+0.079	+3.150	<.001	.001	3	12
BONE	Muscle organ development →	+0.121	+2.709	<.001	<.001	3	12
OESOPHAGUS	Establishment of Golgi localization →	+0.130	+3.149	.001	<.001	3	12
BONE	Myotube cell development →	+0.134	+1.914	<.001	.008	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,777 associations by consensus.

Protein-containing complex disassembly by FLNC expression — STOMACH

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