FLNC

Across TCGA cell cohorts, FLNC mutation is significantly associated with the RNA expression of many other genes, with 1,798 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLNC-associated genes across cancer lineages are APOM, MAP3K9, and ENO2. Each is linked with FLNC in more than 2 cancer types. Because this analysis shows association rather than direction, both FLNC-to-partner and partner-to-FLNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOM grouped by FLNC-low versus FLNC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNC→partner) and Y-score (partner→FLNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APOM →	-0.788	-3.584	<.001	<.001	3	3
LUNG_NSCLC_LUAD	MAP3K9 →	+0.747	+2.451	.002	<.001	3	3
BLOOD_Lymphoma	ENO2 →	+1.880	+2.584	.004	.006	3	3
BLOOD_Leukemia	PGAP1 →	+1.009	+2.548	<.001	.006	3	3
LARGE_INTESTINE	SLC25A51 →	+0.526	+2.584	<.001	.002	3	3
LARGE_INTESTINE	PRSS53 →	+0.357	+1.721	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,798 associations by consensus.

APOM by FLNC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →