FLNB

Across TCGA patient cohorts, FLNB mutation is significantly associated with the RNA expression of many other genes, with 7,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLNB-associated genes across cancer lineages are CENPU, ZNF367, and CHAF1A. Each is linked with FLNB in more than 4 cancer types. Because this analysis shows association rather than direction, both FLNB-to-partner and partner-to-FLNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by FLNB-low versus FLNB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNB→partner) and Y-score (partner→FLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.518	+1.447	<.001	<.001	3	5
UCEC	ZNF367 →	+0.561	+1.643	<.001	<.001	3	5
UCEC	CHAF1A →	+0.600	+2.343	<.001	<.001	3	5
UCEC	ALAS1 →	+0.316	+1.584	.002	.001	3	5
UCEC	TIPIN →	+0.448	+1.786	<.001	<.001	3	5
STAD	TIMM21 →	+0.459	+2.165	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,807 associations by consensus.

CENPU by FLNB expression — UCEC

Explore this box plot interactively →