FLG2

Across TCGA pan-cancer cohorts, FLG2 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated FLG2 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FLG2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FLG2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, ESCA, and COAD are the cancer types where FLG2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.896	0.300	.008	28	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	24	view →
COAD	OS	Median	III,IV	0.056	0.783	<.001	24	view →
ACC	DFS	Median	All	0.068	0.667	.005	12	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	8	view →
LGG	OS	Median	All	0.257	0.801	<.001	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
LUSC	DFS	Median	All	0.927	0.747	.020	6	view →
SKCM	DFS	Median	All	0.151	0.251	.017	6	view →
DLBC	OS	Median	All	0.613	0.945	.049	3	view →
BLCA	DFS	Median	IV	0.266	0.478	.046	3	view →
STAD	DFS	Median	II,III,IV	1.000	0.665	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

FLG2–UCEC (DFS)

Open the UCEC breakdown →