FLG2

Across TCGA pan-cancer cohorts, FLG2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FLG2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FLG2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FLG2 is over-expressed in tumor, although a few such as STAD and HNSC show the opposite, repressed pattern.

KICH, STAD, and LUSC are the cancer types where FLG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	+0.049	.024	3	view →
STAD	All	III,IV	−0.035	.016	3	view →
LUSC	All	All	+0.114	.008	2	view →
KIRP	All	IV	+0.040	.004	2	view →
HNSC	All	III,IV	−0.818	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FLG2–KICH

Open the KICH breakdown →