FLG2

Across TCGA patient cohorts, FLG2 protein abundance is significantly associated with the RNA expression of many other genes, with 500 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FLG2-associated genes across cancer lineages are PLEK2, TMEM109, and TAF12. Each is linked with FLG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLG2-to-partner and partner-to-FLG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FLG2 versus PLEK2 in OV, with a Pearson correlation of -0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG2→partner) and Y-score (partner→FLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLEK2 →	-0.840	-0.563	.003	.002	3	1
OV	TMEM109 →	+0.747	+0.776	.001	<.001	3	1
OV	TAF12 →	-0.525	-0.768	<.001	<.001	3	1
OV	FKBP9 →	+0.941	+0.511	.004	.002	3	1
OV	NEURL2 →	+0.540	+0.515	<.001	<.001	3	1
OV	PLAAT1 →	-1.328	-0.645	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 500 associations by consensus.

FLG2 vs PLEK2 — OV

Explore this scatter interactively →