FLG2

Across TCGA patient cohorts, FLG2 mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLG2-associated genes across cancer lineages are Caspase-7-cleavedD198, Caveolin-1, and Cyclin-B1. Each is linked with FLG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FLG2-to-partner and partner-to-FLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FLG2-low versus FLG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG2→partner) and Y-score (partner→FLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.169	+2.708	<.001	.003	3	4
LUAD	Caveolin-1 →	-0.641	-2.502	.005	.001	3	3
UCEC	Cyclin-B1 →	+0.652	+1.874	<.001	<.001	3	3
BRCA	PAI-1 →	+0.653	+3.328	<.001	.005	3	3
UCEC	eIF4E →	+0.163	+2.070	.005	.001	3	3
STAD	FASN →	+0.621	+2.716	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

Caspase-7-cleavedD198 by FLG2 expression — COAD

Explore this box plot interactively →