FLG2

Across TCGA cell cohorts, FLG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 885 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FLG2-associated GO terms across cancer lineages are mRNA splice site recognition, Negative regulation of RNA splicing, and Negative regulation of mRNA processing. Each is linked with FLG2 in more than 6 cancer types. Because this analysis shows association rather than direction, both FLG2-to-partner and partner-to-FLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by FLG2-low versus FLG2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG2→partner) and Y-score (partner→FLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	mRNA splice site recognition →	+0.074	+0.054	.003	<.001	3	7
SOFT_TISSUE	Negative regulation of RNA splicing →	+0.045	+0.046	.009	.001	3	6
SOFT_TISSUE	Negative regulation of mRNA processing →	+0.059	+0.066	.004	<.001	3	6
BONE	DNA double-strand break processing involved in repair via single-strand annealing →	+0.093	+0.062	<.001	<.001	3	5
SKIN	Negative regulation of DNA-templated transcription, elongation →	+0.084	+0.084	<.001	.001	3	5
BONE	Double-strand break repair via single-strand annealing →	+0.093	+0.062	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 885 associations by consensus.

mRNA splice site recognition by FLG2 expression — SOFT_TISSUE

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