FLG2

Across TCGA cell cohorts, FLG2 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FLG2-associated genes across cancer lineages are ACP4, CAMSAP3, and SRRM4. Each is linked with FLG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLG2-to-partner and partner-to-FLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACP4 grouped by FLG2-low versus FLG2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG2→partner) and Y-score (partner→FLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ACP4 →	+0.047	+2.374	.004	.002	3	2
OESOPHAGUS	CAMSAP3 →	+0.891	+3.169	.002	.005	3	2
LIVER	SRRM4 →	+0.069	+4.000	<.001	.001	3	2
LIVER	MEIKIN →	+0.036	+3.459	.001	.004	3	2
SOFT_TISSUE	SPRR2G →	+0.269	+3.193	.003	.004	3	2
OVARY	CCR8 →	+0.112	+3.070	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

ACP4 by FLG2 expression — OESOPHAGUS

Explore this box plot interactively →