FLG

Across TCGA pan-cancer cohorts, FLG mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FLG data layer compared with 23 for mass-spec protein and 18 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FLG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FLG expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where FLG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.341	0.774	.014	5	view →
UCEC	OS	Median	II,III,IV	1.000	0.484	.015	4	view →
CCRCC	OS	Median	III,IV	0.439	0.978	.009	4	view →
GBM	OS	Median	All	0.451	0.872	.022	3	view →
LSCC	DFS	Tertile	II,III,IV	0.938	0.640	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FLG–LUAD (DFS)

Open the LUAD breakdown →