FLG

Across TCGA pan-cancer cohorts, FLG RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FLG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FLG RNA is repressed in tumor relative to normal tissue. In most cancer types FLG is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

KIRC, UCEC, and BRCA are the cancer types where FLG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.510	<.001	10	view →
UCEC	All	All	−0.330	.002	8	view →
BRCA	All	All	−0.168	<.001	6	view →
LIHC	Male	All	+0.059	.013	3	view →
LUSC	Male	All	+0.377	<.001	2	view →
CHOL	All	All	+0.272	.006	2	view →
THCA	All	II,III,IV	−0.183	.003	2	view →
KIRP	Male	All	−0.319	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FLG–KIRC

Open the KIRC breakdown →