FLG

Across TCGA patient cohorts, FLG RNA expression is significantly associated with the protein abundance of many other proteins, with 10,663 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FLG-associated proteins across cancer lineages are COL3A1, EPN2, and MAP1B. Each is linked with FLG in more than 3 cancer types. Because this analysis shows association rather than direction, both FLG-to-partner and partner-to-FLG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FLG versus COL3A1 in BRCA, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG→partner) and Y-score (partner→FLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL3A1 →	+0.597	+0.178	<.001	<.001	3	4
UCEC	EPN2 →	+0.251	+0.699	.003	.003	3	4
LSCC	MAP1B →	+0.858	+0.880	<.001	<.001	3	4
LSCC	MAP1B_S1265 →	+0.704	+0.825	<.001	<.001	3	4
BRCA	TIMP2 →	+0.580	+0.137	<.001	<.001	3	4
BRCA	PCOLCE →	+0.623	+0.145	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,663 associations by consensus.

FLG vs COL3A1 — BRCA

Explore this scatter interactively →