FLG

Across TCGA patient cohorts, FLG protein abundance is significantly associated with the RNA expression of many other genes, with 2,454 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FLG-associated genes across cancer lineages are TMEM109, RNASEL, and DAB2. Each is linked with FLG in more than 2 cancer types. Because this analysis shows association rather than direction, both FLG-to-partner and partner-to-FLG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FLG versus TMEM109 in GBM, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG→partner) and Y-score (partner→FLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM109 →	+0.616	+1.286	.009	<.001	3	3
LUAD	RNASEL →	+0.735	+1.505	<.001	<.001	3	2
GBM	DAB2 →	+1.524	+0.987	<.001	.001	3	2
HNSC	KRT80 →	+1.137	+1.117	.001	<.001	3	2
LUAD	PDGFA →	+0.945	+1.240	.009	.005	3	2
LSCC	RAB9B →	-0.664	-1.934	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,454 associations by consensus.

FLG vs TMEM109 — GBM

Explore this scatter interactively →