FLG

Across TCGA patient cohorts, FLG mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible FLG-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and FoxM1. Each is linked with FLG in more than 6 cancer types. Because this analysis shows association rather than direction, both FLG-to-partner and partner-to-FLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FLG-low versus FLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG→partner) and Y-score (partner→FLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.380	+1.302	.001	.001	3	7
COAD	Caspase-7-cleavedD198 →	+0.944	+1.593	<.001	<.001	3	6
STAD	FoxM1 →	+0.146	+1.700	.035	.035	3	5
STAD	Bim →	+0.171	+2.000	.013	.006	3	5
SKCM	CDK1 →	+0.079	+0.750	.033	.033	3	5
UCEC	4E-BP1 →	+0.251	+1.169	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

Cyclin-B1 by FLG expression — UCEC

Explore this box plot interactively →