FLG

Across TCGA cell cohorts, FLG RNA expression is significantly associated with the go_rna of many other GO terms, with 2,357 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FLG-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Regulation of protein K48-linked ubiquitination, and Positive regulation of RNA polymerase II transcription preinitiation complex assembly. Each is linked with FLG in more than 8 cancer types. Because this analysis shows association rather than direction, both FLG-to-partner and partner-to-FLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by FLG-low versus FLG-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG→partner) and Y-score (partner→FLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.089	+0.340	<.001	.005	2	9
STOMACH	Regulation of protein K48-linked ubiquitination →	+0.138	+1.177	<.001	<.001	2	9
SKIN	Positive regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.113	+0.815	.001	.008	3	7
STOMACH	Positive regulation of protein localization to nucleus →	+0.091	+1.107	<.001	.001	3	7
PANCREAS	Regulation of telomerase RNA localization to Cajal body →	+0.092	+0.896	<.001	.003	3	7
BONE	Cilium movement →	-0.075	-1.387	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,357 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by FLG expression — BREAST

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