FLG

Across TCGA cell cohorts, FLG mutation is significantly associated with the RNA expression of many other genes, with 2,205 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible FLG-associated genes across cancer lineages are SRGAP2B, ADAMTS13, and PDE6C. Each is linked with FLG in more than 3 cancer types. Because this analysis shows association rather than direction, both FLG-to-partner and partner-to-FLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRGAP2B grouped by FLG-low versus FLG-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLG→partner) and Y-score (partner→FLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SRGAP2B →	+0.748	+2.455	.007	.009	3	4
LUNG_NSCLC_LUAD	ADAMTS13 →	+0.571	+1.807	.001	.003	3	4
OVARY	PDE6C →	+0.062	+2.169	.001	<.001	3	4
OVARY	PLCD4 →	+0.836	+1.906	.003	<.001	3	4
OVARY	DEDD →	+0.539	+1.844	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	KIF27 →	+0.373	+3.137	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,205 associations by consensus.

SRGAP2B by FLG expression — SOFT_TISSUE

Explore this box plot interactively →