FLCN

Across TCGA pan-cancer cohorts, FLCN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FLCN data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FLCN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FLCN expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where FLCN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.931	0.773	.007	20	view →
PDAC	OS	Median	III,IV	0.984	0.549	.002	10	view →
LUAD	OS	Median	III,IV	0.803	0.451	.034	9	view →
UCEC	DFS	Quartile	All	0.925	0.722	.021	6	view →
OV	DFS	Median	All	0.585	0.942	.012	4	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	1	view →
LSCC	OS	Tertile	All	0.940	0.813	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FLCN–HNSC (OS)

Open the HNSC breakdown →