FLCN

Across TCGA patient cohorts, FLCN protein abundance is significantly associated with the RNA expression of many other genes, with 1,890 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FLCN-associated genes across cancer lineages are FOXRED2, ARRB2, and TRAPPC1. Each is linked with FLCN in more than 1 cancer types. Because this analysis shows association rather than direction, both FLCN-to-partner and partner-to-FLCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FLCN versus FOXRED2 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLCN→partner) and Y-score (partner→FLCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FOXRED2 →	+0.566	+0.172	.002	.008	3	2
LSCC	ARRB2 →	+0.355	+0.144	<.001	.009	3	2
LUAD	TRAPPC1 →	+0.360	+0.175	.002	<.001	3	2
BRCA	ADORA2B →	+0.834	+0.178	<.001	.009	3	2
GBM	ATPAF2 →	+0.339	+0.180	<.001	.003	3	2
LSCC	FLII →	+0.448	+0.218	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,890 associations by consensus.

FLCN vs FOXRED2 — GBM

Explore this scatter interactively →