FLCN

Across TCGA cell cohorts, FLCN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,575 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FLCN-associated GO terms across cancer lineages are Negative regulation of brown fat cell differentiation, Negative regulation of lysosome organization, and Regulation of lysosome organization. Each is linked with FLCN in more than 18 cancer types. Because this analysis shows association rather than direction, both FLCN-to-partner and partner-to-FLCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of brown fat cell differentiation grouped by FLCN-low versus FLCN-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLCN→partner) and Y-score (partner→FLCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of brown fat cell differentiation →	+0.228	+1.395	<.001	<.001	3	19
LIVER	Negative regulation of lysosome organization →	+0.182	+1.576	<.001	<.001	3	19
LIVER	Regulation of lysosome organization →	+0.150	+1.613	<.001	<.001	3	18
OESOPHAGUS	Retrograde transport, endosome to Golgi →	+0.083	+1.132	<.001	.002	3	17
LUNG_NSCLC_LUSC	Regulation of vacuole organization →	+0.074	+1.007	.003	<.001	3	17
OESOPHAGUS	Cytosolic transport →	+0.070	+1.234	<.001	.002	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,575 associations by consensus.

Negative regulation of brown fat cell differentiation by FLCN expression — BREAST

Explore this box plot interactively →