FLCN

Across TCGA cell cohorts, FLCN mutation is significantly associated with the RNA expression of many other genes, with 181 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLCN-associated genes across cancer lineages are OR9A2, TAS2R41, and PRR23C. Each is linked with FLCN in more than 1 cancer types. Because this analysis shows association rather than direction, both FLCN-to-partner and partner-to-FLCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by FLCN-low versus FLCN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLCN→partner) and Y-score (partner→FLCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR9A2 →	+0.012	+2.347	.001	.007	3	2
LARGE_INTESTINE	TAS2R41 →	+0.028	+2.760	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	2
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
SKIN	OR5B17 →	+0.026	+5.415	<.001	.004	3	1
SKIN	OR2A5 →	+0.155	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

OR9A2 by FLCN expression — LARGE_INTESTINE

Explore this box plot interactively →