FLACC1

Across TCGA patient cohorts, FLACC1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLACC1-associated genes across cancer lineages are ASNS, Cyclin-B1, and EGFR_pY1068. Each is linked with FLACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLACC1-to-partner and partner-to-FLACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FLACC1-low versus FLACC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLACC1→partner) and Y-score (partner→FLACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.465	+2.584	.001	.010	3	2
UCEC	Cyclin-B1 →	+0.525	+2.999	.020	.035	3	2
UCEC	EGFR_pY1068 →	-0.232	-1.906	.021	.016	3	1
UCEC	MEK1 →	+0.478	+2.415	.001	.003	3	1
UCEC	Notch1 →	+0.139	+2.183	.014	.033	3	1
UCEC	p62 Lck ligand →	+0.439	+2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ASNS by FLACC1 expression — UCEC

Explore this box plot interactively →