FKRP

Across TCGA cell cohorts, FKRP mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FKRP-associated genes across cancer lineages are OR5B3, KRTAP11-1, and BPIFB3. Each is linked with FKRP in more than 1 cancer types. Because this analysis shows association rather than direction, both FKRP-to-partner and partner-to-FKRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5B3 grouped by FKRP-low versus FKRP-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKRP→partner) and Y-score (partner→FKRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5B3 →	+0.033	+4.415	<.001	.007	3	1
SKIN	KRTAP11-1 →	+0.016	+4.415	<.001	.007	3	1
SKIN	BPIFB3 →	+0.022	+5.022	<.001	.002	3	1
SKIN	C5orf52 →	+0.046	+4.415	<.001	.007	3	1
SKIN	AVPR1B →	+0.009	+4.415	<.001	.007	3	1
SKIN	CASP12 →	+0.045	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR5B3 by FKRP expression — SKIN

Explore this box plot interactively →