FKBP8

Across TCGA cell cohorts, FKBP8 mutation is significantly associated with the mutation status of many other genes, with 3,021 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FKBP8-associated genes across cancer lineages are AP3D1, SCARF1, and PPP1R13B. Each is linked with FKBP8 in more than 3 cancer types. Because this analysis shows association rather than direction, both FKBP8-to-partner and partner-to-FKBP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP3D1 grouped by FKBP8-low versus FKBP8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP8→partner) and Y-score (partner→FKBP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AP3D1 →	+3.582	+4.084	<.001	<.001	1	4
OVARY	SCARF1 →	+5.415	+5.415	.004	.004	1	4
OVARY	PPP1R13B →	+4.415	+4.977	.007	.007	1	4
OVARY	DMTF1 →	+4.415	+4.977	.007	.007	1	4
OVARY	ESAM →	+5.415	+5.415	.004	.004	1	4
BLOOD_Leukemia	ADAMTS13 →	+2.997	+3.697	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,021 associations by consensus.

AP3D1 by FKBP8 expression — BLOOD_Leukemia

Explore this box plot interactively →