FKBP4

Across TCGA patient cohorts, FKBP4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP4-associated genes across cancer lineages are Rictor_pT1135, FOXO3a_pS318_S321, and Ku80. Each is linked with FKBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP4-to-partner and partner-to-FKBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by FKBP4-low versus FKBP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP4→partner) and Y-score (partner→FKBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.095	-1.807	.024	.027	3	2
UCEC	FOXO3a_pS318_S321 →	-0.137	-2.584	.007	.010	3	1
UCEC	Ku80 →	+0.280	+1.820	.004	.016	3	1
UCEC	mTOR_pS2448 →	-0.148	-1.807	.016	.027	3	1
UCEC	Notch1 →	+0.247	+3.000	<.001	.001	3	1
UCEC	p27_pT198 →	+0.131	+2.321	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rictor_pT1135 by FKBP4 expression — UCEC

Explore this box plot interactively →